Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing
“The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how theyact to affect gene expression andfunction.It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property.Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected.Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.”
The global economy and our way of life are based on the exploitation of fossil fuels, which not only threaten massive environmental and social disruption through global warming but, at present rates of consumption, will run out within decades, causing huge industrial dislocation and economic collapse. Even before then, the conflicts it causes in…
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