Home » Nonfiction » Thomas Decker » Jak-Stat Signaling : From Basics to Disease

December 07 , 2009

Jak-Stat Signaling : From Basics to Disease


JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.

Download xml

Read also

The London Stone

The prophecy has come to pass.The London Stone has been stolen and the Dark King rules the Nowhere. Only Mona and the new Seer dare to stand against him, leading an underground rebellion in the frozen wasteland ... but what chance do they have, against both the Army of the Mad and Arnold Mather's soldiers?There is still hope: if they can recruit a…

How to download book

Buy this book

You can buy this book now only for $125.69. This is the lowest price for this book.

Buy book

Download book free

If you want to download this book for free, please register, approve your account and get one book for free.


After that you may download book «Jak-Stat Signaling : From Basics to Disease»:

Download Microsoft Reader (LIT):


Download ePub:


Download FB2:


Download Adobe DRM: